Analysis Note

Controlbrain lysate

Application

Research CategoryNeuroscience

This Anti-NUDEL Antibody is validated for use in WB for the detection of NUDEL.

Western Blot: 1:5000L

Research Sub CategoryDevelopmental Neuroscience

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

NudE nuclear distribution gene E homolog (A. nidulans)-like 1 (NUDEL), also known as NDEL1, is a human gene. This gene encodes a thiol-activated peptidase that is phosphorylated in M phase of the cell cycle. Phosphorylation regulates the cell cycle-dependent distribution of this protein, with a fraction of the protein bound strongly to centrosomes in interphase and localized to mitotic spindles in early M phase. This protein plays a role in nervous system development and is linked to LIS-1, the disease gene for a form of lissencephaly, a disorder of cortical development. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Immunogen

Synthetic Linear Peptide.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Physical form

Serum with 0.05% NaN₃

Quality

Routinely evaluated by immunoblot.

Specificity

Recognizes rat NUDEL

Storage and Stability

Maintain at -20°C in undiluted aliquots for up to 1 year after date of receipt.

Target description

38 kDa